| Date | Location | Result | |
| Nov 20, 2010 | Omaha, Neb. | Creighton 3, Southern Illinois 1 (28-26,25-13,26-28,25-15) | Box score |
| Nov 19, 2010 | Des Moines, Iowa | Drake 3, Southern Illinois 2 (21-25,25-16,25-22,23-25,15-12) | Box score |
| Nov 13, 2010 | Carbondale, Ill. | Wichita State 3, Southern Illinois 1 (25-18,19-25,25-17,25-14) | Box score |
| Nov 12, 2010 | Carbondale, Ill. | Missouri State 3, Southern Illinois 0 (25-17,26-24,25-22) | Box score |
| Nov 06, 2010 | Terre Haute, Ind. | Indiana State 3, Southern Illinois 2 (14-25,25-17,25-21,18-25,15-13) | Box score |
| Nov 05, 2010 | Normal, Ill. | Illinois State 3, Southern Illinois 0 (27-25,25-20,25-17) | Box score |
| Oct 30, 2010 | Carbondale, Ill. | Southern Illinois 3, Bradley 1 (25-19,21-25,25-23,25-12) | Box score |
| Oct 29, 2010 | Carbondale, Ill. | UNI 3, Southern Illinois 0 (25-12,25-20,25-12) | Box score |
| Oct 22, 2010 | Carbondale, Ill. | Southern Illinois 3, Evansville 2 (26-24,21-25,23-25,25-21,15-8) | Box score |
| Oct 16, 2010 | Springfield, Mo. | Missouri State 3, Southern Illinois 0 (26-24,25-21,25-13) | Box score |
| Oct 15, 2010 | Wichita, Kan. | Wichita State 3, Southern Illinois 0 (25-18,25-20,25-19) | Box score |
| Oct 09, 2010 | Carbondale, Ill. | Southern Illinois 3, Illinois State 1 (28-26,25-22,25-27,25-15) | Box score |
| Oct 08, 2010 | Carbondale, Ill. | Southern Illinois 3, Indiana State 2 (23-25,28-30,25-15,25-21,15-9) | Box score |
| Oct 02, 2010 | Cedar Falls, Iowa | UNI 3, Southern Illinois 0 (25-23,25-18,25-13) | Box score |
| Oct 01, 2010 | Peoria, Ill. | Southern Illinois 3, Bradley 0 (25-20,25-16,25-12) | Box score |
| Sep 25, 2010 | Evansville, Ind. | Evansville 3, Southern Illinois 0 (25-23,25-18,25-18) | Box score |
| Sep 18, 2010 | Carbondale, Ill. | Drake 3, Southern Illinois 0 (25-21,25-19,25-17) | Box score |
| Sep 17, 2010 | Carbondale, Ill. | Creighton 3, Southern Illinois 0 (26-24,25-22,25-20) | Box score |
| Sep 14, 2010 | Carbondale, Ill. | Southern Illinois 3, UT Martin 0 (25-19,25-23,25-23) | Box score |
| Sep 11, 2010 | Carbondale, Ill. | Southern Illinois 3, South Florida 0 (25-15,25-12,25-16) | Box score |
| Sep 11, 2010 | Carbondale, Ill. | Southern Illinois 3, Southeast Missouri 1 (25-18,23-25,25-13,25-19) | Box score |
| Sep 10, 2010 | Carbondale, Ill. | Southern Illinois 3, Mississippi State 0 (25-22,25-18,25-21) | Box score |
| Sep 04, 2010 | Storrs, Conn. | Southern Illinois 3, Connecticut 0 (25-20,25-18,25-13) | Box score |
| Sep 04, 2010 | Storrs, Conn. | Southern Illinois 3, HARTFORD 0 (25-15,25-13,25-12) | Box score |
| Sep 03, 2010 | Storrs, Conn. | Southern Illinois 3, Brown 0 (27-25,25-11,25-11) | Box score |
| Aug 29, 2010 | Iowa City, IA | Southern Illinois 3, Alabama 0 (26-24,25-19,25-23) | Box score |
| Aug 28, 2010 | Iowa City, IA | Iowa 3, Southern Illinois 2 (23-25,22-25,31-29,25-19,17-15) | Box score |
| Aug 27, 2010 | Iowa City, IA | Southern Illinois 3, Green Bay 0 (25-14,25-9,25-17) | Box score |
