| Date | Location | Result | |
| 03-09-06 | Hammons Student Center--Springfield, Mo. | Creighton 54, Southern Illinois 51 | Box score |
| 03-04-06 | SIU Arena--Carbondale, Ill. | Southern Illinois 59, Illinois State 58 | Box score |
| 03-02-06 | SIU Arena--Carbondale, Ill. | Indiana State 82, Southern Illinois 70 | Box score |
| 02-26-06 | SIU Arena--Carbondale, Ill. | Evansville 66, Southern Illinois 63 | Box score |
| 02-19-06 | Knapp Center--Des Moines, Iowa | Drake 81, Southern Illinois 55 | Box score |
| 02-17-06 | Sapp Fieldhouse--Omaha, Neb. | Southern Illinois 45, Creighton 44 | Box score |
| 02-12-06 | SIU Arena--Carbondale, Ill. | Wichita State 84, Southern Illinois 77 | Box score |
| 02-10-06 | SIU Arena--Carbondale, Ill. | Missouri State 62, Southern Illinois 55 | Box score |
| 02-04-06 | West Gym--Cedar Falls, Iowa | Northern Iowa 49, Southern Illinois 40 | Box score |
| 02-02-06 | Robertson Field House--Peoria, Ill. | Bradley 52, Southern Illinois 43 | Box score |
| 01-28-06 | Roberts Stadium--Evansville, Ind. | Evansville 73, Southern Illinois 53 | Box score |
| 01-21-06 | SIU Arena--Carbondale, Ill. | Southern Illinois 74, Drake 66 | Box score |
| 01-19-06 | SIU Arena--Carbondale, Ill. | Southern Illinois 85, Creighton 63 | Box score |
| 01-14-06 | Charles Koch Arena--Wichita, Kan. | Wichita State 66, Southern Illinois 57 | Box score |
| 01-12-06 | Hammons Student Center--Springfield, Mo. | Missouri State 69, Southern Illinois 52 | Box score |
| 01-07-06 | SIU Arena--Carbondale, Ill. | Southern Illinois 66, Bradley 64 | Box score |
| 01-05-06 | SIU Arena--Carbondale, Ill. | Northern Iowa 59, Southern Illinois 48 | Box score |
| 01-01-06 | Hulman Center--Terre Haute, Ind. | Indiana State 74, Southern Illinois 61 | Box score |
| 12-30-05 | Redbird Arena--Normal, Ill. | Southern Illinois 87, Illinois State 65 | Box score |
| 12-22-05 | Savvis Center--St. Louis, Mo. | Saint Louis 63, Southern Illinois 61 | Box score |
| 12-18-05 | Mizzou Arena -- Columbia, Mo. | Missouri 96, Southern Illinois 69 | Box score |
| 12-10-05 | SIU Arena -- Carbondale, Ill. | Southern Illinois 75, South Dakota State 59 | Box score |
| 12-05-05 | Eblen Center--Cookeville, Tenn. | Tennessee Tech 70, Southern Illinois 60 | Box score |
| 12-02-05 | SIU Arena--Carbondale, Ill. | Indiana 64, Southern Illinois 59 | Box score |
| 11-29-05 | Show Me Center--Cape Girardeau, Mo. | Southeast Missouri State 74, Southern Illinois 63 | Box score |
| 11-25-05 | SIU Arena--Carbondale, Ill. | Southern Illinois 82, South Alabama 61 | Box score |
| 11-22-05 | Regional Special Events Ctr--Murray, Ky. | Southern Illinois 94, Murray State 77 | Box score |
| 11-19-05 | SIU Arena--Carbondale, Ill. | Southern Illinois 55, Weber State 48 | Box score |
